Native Calf Adenosine Deaminase

Names

[ Name ]:
Native Calf Adenosine Deaminase

[Synonym ]:
adenosine deaminase type viii
adenosine deaminase type ix
MFCD00081287
human adenosine deaminase
adenosine deaminase
adenosine deaminase, bovine intestine
ec 3.5.4.4
adenosine deaminase type v
Native Calf Adenosine Deaminase

Biological Activity

[Description]:

Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase

Research Areas >> Inflammation/Immunology

[In Vitro]

Adenosine deaminase (ADA; EC 3.5.4.4) catalyzes the irreversible deamination of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively. Adenosine deaminase is implicated in purine metabolism and distributed in most mammalian tissues. Genetic Adenosine deaminase deficiency results in lymphopenia and severe combined immunodeficiency disease by decreasing the differentiation and maturation of lymphoid cells[1]. Adenosine deaminase is a signaling molecule related to the activation of T lympho-cytes, making it a useful inflammation marker, especially for menin-gitis and tuberculous pleuritis[2].

[References]

[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.

[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823.

[Related Small Molecules]

PENTOSTATIN | AMPD2 inhibitor 1

Chemical & Physical Properties

[ Storage condition ]:
2-8C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase.

Arterioscler. Thromb. Vasc. Biol. 33(3) , 629-36, (2013)

Adenosine dilates human coronary arteries by activating potassium channels in an endothelial cell-independent manner. Cell surface ecto-5'-nucleotidase (CD73) rapidly dephosphorylates extracellular ad...

Ectoenzymes and cholinesterase activity and biomarkers of oxidative stress in patients with lung cancer.

Mol. Cell Biochem. 374(1-2) , 137-48, (2013)

We aimed to examine the nucleoside triphosphate diphosphohydrolases (NTPDase) in lymphocytes; adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in serum; and acetylcholinesterase (AChE), supe...

Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils.

J. Pharm. Pharmacol. 65(1) , 115-22, (2013)

To evaluate the effect of β-sitosterol on ⁴⁵Ca²⁺ uptake in activated murine neutrophils, and upon myeloperoxidase and adenosine deaminase activity, and interleukin-1β (IL-1β) and tumour necrosis facto...