H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt

Names

[ Name ]:
H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt

[Synonym ]:
h-ala-ala-pro-val-cmk
ala-ala-pro-val-chloromethylketone
ala-ala-pro-val-cmk

Biological Activity

[Description]:

Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

Research Areas >> Inflammation/Immunology

[In Vivo]

Methoxysuccinyl-Ala-Ala-Pro-Val chloromethylketone (oropharyngeal aspiration; 85 μM, 40 μL; days 1, 4, and 7) blocks NE-induced cupped cell chemotaxis and significantly reduces Muc5ac gene and protein expression in male Balb/c mice[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₉ClN₄O₄

[ Molecular Weight ]:
388.89000

[ Exact Mass ]:
388.18800

[ PSA ]:
121.60000

[ LogP ]:
1.19800

Synthetic Route

Click to get detail synthetic route

Related Compounds

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