Hydroxypropyl Cellulose

Names

[ Name ]:
Hydroxypropyl Cellulose

[Synonym ]:
β-D-Glucopyranoside, 2-hydroxypropyl 2,3,6-tris-O-(2-hydroxypropyl)-4-O-[2,3,4,6-tetrakis-O-(2-hydroxypropyl)-α-D-glucopyranosyl]-
Klucel
MFCD00132688
2-Hydroxypropyl 2,3,6-tris-O-(2-hydroxypropyl)-4-O-[2,3,4,6-tetrakis-O-(2-hydroxypropyl)-α-D-glucopyranosyl]-β-D-glucopyranoside

Biological Activity

[Description]:

Hydroxypropyl Cellulose is somewhat amphiphilic in character and is a surfactant. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Werbowyj R S, et al. Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions[J]. Molecular Crystals and Liquid Crystals, 1976, 34(4): 97-103.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
891.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₇₀O₁₉

[ Molecular Weight ]:
806.930

[ Flash Point ]:
492.8±34.3 °C

[ Exact Mass ]:
806.451111

[ LogP ]:
-1.24

[ Appearance of Characters ]:
powder | White to light cream

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.532

[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ Water Solubility ]:
polar oganic solvents: soluble

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
S24/S25

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
NF9050000

Articles

Polymer-directed crystallization of atorvastatin.

J. Pharm. Sci. 101(8) , 2941-51, (2012)

Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystal...

Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion.

Drug Dev. Ind. Pharm. 39(2) , 290-8, (2013)

The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecu...

Improved supersaturation and oral absorption of dutasteride by amorphous solid dispersions.

Chem. Pharm. Bull. 60(11) , 1468-73, (2012)

In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form s...