Follicle-stimulating hormone

[Description]:

Follicle-stimulating hormone is a heterodimer glycoprotein expressed by gonadotropin in the anterior pituitary gland. Follicle-stimulating hormone affects the fertility and reproductive efficiency of animals[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[In Vitro]

卵泡刺激素 (FSH) 刺激卵巢颗粒细胞抑制素的产生，从而降低 FSH 的产生[1]。

[In Vivo]

卵泡刺激素 (1-4 mg/只羊; 肌肉注射; 每天 2 次, 共 2 天) 在植入 Norgestomet (HY-121677) 的山羊中，增加黄体 (CL) 总数、恢复的胚胎数和可转移的优质胚胎数[2]。 Animal Model: Non-lactating mixed breed dairy goats implanted with Norgestomet[1] Dosage: 1 mg, 2 mg, 3 mg, and 4 mg; treated after implanted 6 mg Norgestomet for 11 d Administration: Intramuscular injection; twice daily for 2 days, with 12 h interval Result: Increased the total corpus luteum (CL), and decreased the number of abnormal CL. Increased the number of embryos recovered and high-quality embryos.

[References]

[1]. Das N, et al. Molecular regulation of follicle-stimulating hormone synthesis, secretion and action. J Mol Endocrinol. 2018 Apr;60(3):R131-R155.

[2]. Pendleton R J, et al. Follicle stimulating hormone versus pregnant mare serum gonadotropin for superovulation of dairy goats. Small Ruminant Research, 1992, 8(3): 217-224.

[ Appearance of Characters ]:
white powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL, soluble

[ Hazard Codes ]:
B

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LP6330000

Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging.

Endocrinology 155(6) , 2287-300, (2014)

Women experience a series of specific transitions in their reproductive function with age. Shortening of the menstrual cycle begins in the mid to late 30s and is regarded as the first sign of reproduc...

Regulatory Role of Gonadotropins and Local Factors Produced by Ovarian Follicles on In Vitro Resistin Expression and Action on Porcine Follicular Steroidogenesis.

Biol. Reprod. 92 , 142, (2015)

Resistin, a hormone secreted by adipocytes, is thought to be important in reproduction. Our previous study demonstrated resistin expression in porcine ovarian follicles and its direct effect on steroi...

Longer anogenital distance is associated with higher testosterone levels in women: a cross-sectional study.

BJOG 121(11) , 1359-64, (2014)

Animal models have suggested that anogenital distance (AGD) at birth reflects androgen levels during in utero development and predicts adult AGD. A recent study showed an association between perineal ...

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