BRD7586

Names

[ CAS No. ]:
895460-70-5

[ Name ]:
BRD7586

Biological Activity

[Description]:

BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9. BRD7586 is the smallest known anti-CRISPR[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> CRISPR/Cas9

[In Vitro]

BRD7586在细胞中特异性地与 SpCas9 结合，但不与 Cas12a 结合[1]。 BRD7586 (0-20 μM; 24 h) 在 HiBiT-knock-in 试验中，呈剂量依赖性地抑制 SpCas9[1]。 BRD7586 (20 μM; 48 h) 增强 HEK293T 细胞中中靶与脱靶的比值[1]。

[References]

[1]. Lim D, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022 Dec;24(12):1766-1775.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄ClN₃O₃S₂

[ Molecular Weight ]:
407.89436

Related Compounds

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