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Mesalamine impurity P

Names

[ CAS No. ]:
887256-40-8

[ Name ]:
Mesalamine impurity P

[Synonym ]:
5-Amino-2-hydroxy-4'-sulfo-3-biphenylcarboxylic acid
[1,1'-Biphenyl]-3-carboxylic acid, 5-amino-2-hydroxy-4'-sulfo-
Mesalazine Impurity 16

Biological Activity

[Description]:

Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cytoskeleton >> PAK
Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> PAK

[Target]

PPAR

PAK1

NF-κB


[References]

[1]. Kyle Dammann, et al.PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C13H11NO6S

[ Molecular Weight ]:
309.294

[ Exact Mass ]:
309.030701

[ LogP ]:
-0.01

[ Index of Refraction ]:
1.694

[ Storage condition ]:
-20°C

Related Compounds