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Notoginsenoside Fc

Names

[ CAS No. ]:
88122-52-5

[ Name ]:
Notoginsenoside Fc

[Synonym ]:
β-D-Glucopyranoside, (3β,12β)-12-hydroxy-20-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl O-β-D-xylopyranosyl-(1-&gt;2)-O-β-D-glucopyranosyl-(1->2)-
Dammarane, β-D-glucopyranoside deriv.
(3β,12β)-12-Hydroxy-20-{[6-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]oxy}dammar-24-en-3-yl β-D-xylopyranosyl-(1->;2)-β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside
Notoginsenoside Fc

Biological Activity

[Description]:

Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Notoginsenoside Fc (20 μM; for 24 h) markedly upregulates the expression of LC3B and Beclin 1 and downregulated that of p62 in RAOECs[1].

[In Vivo]

Notoginsenoside Fc (3.5 mg/kg/day) accelerates reendothelialization and alleviates excessive neointimal formation following carotid artery injury in diabetic Sprague-Dawley rats (200±20 g) in vivo[1].

[References]

[1]. Liu J, et al. Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy. J Diabetes Res. 2019 Sep 3;2019:9696521.

Chemical & Physical Properties

[ Density]:
1.47±0.1 g/cm3

[ Molecular Formula ]:
C58H98O26

[ Molecular Weight ]:
1211.383

[ Exact Mass ]:
1210.634644

[ PSA ]:
415.98000

[ LogP ]:
6.60

[ Index of Refraction ]:
1.631

[ Water Solubility ]:
Insuluble (1.9E-3 g/L) (25 ºC)

Related Compounds