88122-52-5

88122-52-5 structure

Name: Notoginsenoside Fc
Chemical Name: β-D-Glucopyranoside, (3β,12β)-12-hydroxy-20-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)
CAS Number: 88122-52-5
Molecular Formula: C₅₈H₉₈O₂₆
Molecular Weight: 1211.383
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-04-25 08:00:00
Modify Date: 2024-01-02 12:22:47
Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy[1].

Name	β-D-Glucopyranoside, (3β,12β)-12-hydroxy-20-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)
Synonyms	β-D-Glucopyranoside, (3β,12β)-12-hydroxy-20-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl O-β-D-xylopyranosyl-(1->2)-O-β-D-glucopyranosyl-(1->2)- Dammarane, β-D-glucopyranoside deriv. (3β,12β)-12-Hydroxy-20-{[6-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]oxy}dammar-24-en-3-yl β-D-xylopyranosyl-(1->;2)-β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside Notoginsenoside Fc

Description	Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Notoginsenoside Fc (20 μM; for 24 h) markedly upregulates the expression of LC3B and Beclin 1 and downregulated that of p62 in RAOECs[1].
In Vivo	Notoginsenoside Fc (3.5 mg/kg/day) accelerates reendothelialization and alleviates excessive neointimal formation following carotid artery injury in diabetic Sprague-Dawley rats (200±20 g) in vivo[1].
References	[1]. Liu J, et al. Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy. J Diabetes Res. 2019 Sep 3;2019:9696521.