CMP-5
Names
[ CAS No. ]:
880813-42-3
[ Name ]:
CMP-5
[Synonym ]:
9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine
Biological Activity
[Description]:
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
[References]
References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase)
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
505.1±48.0 °C at 760 mmHg
[ Molecular Formula ]:
C21H21N3
[ Molecular Weight ]:
315.411
[ Flash Point ]:
259.3±29.6 °C
[ Exact Mass ]:
315.173553
[ LogP ]:
4.23
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.637