Delta-12-Prostaglandin J2

Names

[ Name ]:
Delta-12-Prostaglandin J2

[Synonym ]:
12-PROSTAGLANDIN J2
(5Z,12E,15S)-15-Hydroxy-11-oxoprosta-5,9,12-trien-1-oic acid
(5Z,12E,15S)-11-Oxo-15-hydroxyprosta-5,9,12-triene-1-oic acid
DELTA12-PGJ2
Prosta-5,9,12-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,12E,15S)-
11-OXO-15S-HYDROXY-PROSTA-5Z,9,12E-TRIEN-1-OIC ACID
13,14-dihydro-Delta(12)-prostaglandin J2
13,14-dihydro-δ(12)-prostaglandin J2
DELTA12-PROSTAGLANDIN J2
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2

Biological Activity

[Description]:

Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

Human Endogenous Metabolite

[References]

[1]. Kim BE, et al. Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. Exp Mol Med. 2004;36(5):444-453.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
531.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₀O₄

[ Molecular Weight ]:
334.450

[ Flash Point ]:
289.2±26.6 °C

[ Exact Mass ]:
334.214417

[ PSA ]:
74.60000

[ LogP ]:
4.12

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.558

Related Compounds

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