Benzyl-PEG4-amine

Names

[ CAS No. ]:
86770-76-5

[ Name ]:
Benzyl-PEG4-amine

[Synonym ]:
1-phenyl-2,5,8,11-tetraoxatridecan-13-amine

Biological Activity

[Description]:

Benzyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Boiling Point ]:
390.4±32.0°C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₅NO₄

[ Molecular Weight ]:
283.36300

[ Exact Mass ]:
283.17800

[ PSA ]:
62.94000

[ LogP ]:
1.91200

MSDS

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Safety Information

[ HS Code ]:
2921499090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%