DM-NOFD

Names

[ Name ]:
DM-NOFD

[Synonym ]:
N-Oxalyl-D-phenylalanine dimethyl ester
N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester
Dimethyl N-oxalyl-D-phenylalanine
DM-NOFD
D-Phenylalanine, N-(2-methoxy-1,2-dioxoethyl)-, methyl ester
Methyl N-[methoxy(oxo)acetyl]-D-phenylalaninate

Biological Activity

[Description]:

The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.

[References]

References 1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73. 2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. View Related Products by Target HIF/HIF Prolyl-hydroxylase

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₃H₁₅NO₅

[ Molecular Weight ]:
265.262

[ Exact Mass ]:
265.095032

[ LogP ]:
1.61

[ Index of Refraction ]:
1.518

Related Compounds

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