guanosine 5'-(tetrahydrogen triphosphate)

Names

[ CAS No. ]:
86-01-1

[ Name ]:
guanosine 5'-(tetrahydrogen triphosphate)

[Synonym ]:
Guanosine triphosphate
guanosine 5'-O-(triphosphate)
[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
Guanosine 5'-triphosphoric acid
pppG
D-Guanosine5'-triphosphate
guanosine 5'-(tetrahydrogen triphosphate)
guanosine 5'-triphosphate
Guo-5'-P3
guanosine triphosphate (-Na2)

Biological Activity

[Description]:

Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.

Chemical & Physical Properties

[ Density]:
2.75g/cm3

[ Boiling Point ]:
1028.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆N₅O₁₄P₃

[ Molecular Weight ]:
523.18000

[ Flash Point ]:
575.7ºC

[ Exact Mass ]:
522.99100

[ PSA ]:
328.53000

[ Index of Refraction ]:
1.935

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8793000

CHEMICAL NAME :: Guanosine, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 86-01-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N5-O14-P3

MOLECULAR WEIGHT :: 523.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 100 umol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,52,1975

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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