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Edoxaban M4

Names

[ CAS No. ]:
834919-19-6

[ Name ]:
Edoxaban M4

[Synonym ]:
D21-2393
Cyclohexanecarboxylic acid, 4-[[2-[(5-chloro-2-pyridinyl)amino]-1,2-dioxoethyl]amino]-3-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]-, (1S,3R,4S)-
IV344R972X
(1S,3R,4S)-4-({[(5-Chloro-2-pyridinyl)amino](oxo)acetyl}amino)-3-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexanecarboxylic acid

Biological Activity

[Description]:

Edoxaban M4, an active metabolite of Edoxaban, shows reproducible, but concentration-dependent matrix effects. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor [1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Romain Siriez, et al. Importance of measuring pharmacologically active metabolites of edoxaban: development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method. J Thromb Thrombolysis. 2020 Apr;49(3):395-403.

[2]. Kathrin I Foerster, et al. Simultaneous quantification of direct oral anticoagulants currently used in anticoagulation therapy. J Pharm Biomed Anal. 2018 Jan 30;148:238-244.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C22H25ClN6O5S

[ Molecular Weight ]:
520.99

[ Exact Mass ]:
520.129578

[ LogP ]:
1.70

[ Index of Refraction ]:
1.669

Related Compounds