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3-phosphoglyceric acid

Names

[ CAS No. ]:
820-11-1

[ Name ]:
3-phosphoglyceric acid

[Synonym ]:
D-3-phosphoglycerate
4gwk
3-phospho-D-glyceric acid
(2R)-2-hydroxy-3-phosphonatooxypropanoate
3-phospho-D-glycerate
D-glycerate-3-P
D-Glycerate 3-phosphate
3fjg
3-P-D-glycerate
3-phosphonato-D-glycerate

Biological Activity

[Description]:

3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

[In Vitro]

3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1]. 3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1]. In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1]. RT-PCR[1] Cell Line: Bone marrow-derived macrophages (BMDMs) Concentration: 400 µM Incubation Time: 24 hours Result: Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.

[References]

[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.

Chemical & Physical Properties

[ Molecular Formula ]:
C3H7O7P

[ Molecular Weight ]:
183.03300

[ Exact Mass ]:
182.96900

[ PSA ]:
142.59000

Precursor & DownStream

Precursor

DownStream

Related Compounds