D-(-)-3-Phosphoglyceric acid disodium

Names

[ Name ]:
D-(-)-3-Phosphoglyceric acid disodium

[Synonym ]:
D-3-phosphoglyceric acid,disodium salt
D-Glycerate 3-phosphate disodium salt

Biological Activity

[Description]:

D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalysed process of glycolysis. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Enolase

[References]

[1]. Ramos ML, Justino LL, Gil VM, Burrows HD. NMR and DFT studies of the complexation of W(VI) and Mo(VI) with 3-phospho-D-glyceric and 2-phospho-D-glyceric acids. Dalton Trans. 2009;(43):9616-9624.

[2]. Faller LD, et al. Calorimetric studies of the role of magnesium ions in yeast enolase catalysis. Proc Natl Acad Sci U S A. 1974;71(4):1083-1087.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₅Na₂O₇P

[ Molecular Weight ]:
230.02100

[ Exact Mass ]:
229.95700

[ PSA ]:
139.76000

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H371

[ Precautionary Statements ]:
P260-P305 + P351 + P338

[ Risk Phrases ]:
36/37/38-68/20/21/22-20/21/22

[ Safety Phrases ]:
26-36-45-36/37

[ RIDADR ]:
NONH for all modes of transport

Articles

Reduction of arsenate to arsenite by human erythrocyte lysate and rat liver cytosol - characterization of a glutathione- and NAD-dependent arsenate reduction linked to glycolysis.

Toxicol. Sci. 85 , 847-58, (2005)

Reduction of arsenate (AsV) to the more toxic arsenite (AsIII) is of high toxicological importance, yet in vivo relevant enzymes involved have not been identified. Purine nucleoside phosphorylase (PNP...

Phosphorylation of glyceric acid in aqueous solution using trimetaphosphate.

Orig. Life Evol. Biosph. 26 , 7-13, (1996)

The phosphorylation of glyceric acid is an interesting prebiotic reaction because it converts a simple, potentially prebiotic organic molecule into phosphate derivatives that are central to carbohydra...

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Yang L, Xie M, Yang M, et al.

Nat. Commun. 5 , 4436, (2014)

Related Compounds

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