Acetyllovastatin

Names

[ Name ]:
Acetyllovastatin

[Synonym ]:
4-acetyl lovastatin
(2E)-1-[3-(Acetyloxy)-2,6,6-trimethyl-1-cyclohexen-1-yl]-2-buten-1-one
4-Acetoxy--damascone

Biological Activity

[Description]:

Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[Target]

IC50: 79 μg/mL (The enzyme acetylcholinesterase)[1]

[References]

[1]. Cazar, et al. Antimicrobial Butyrolactone I Derivatives from the Ecuadorian Soil Fungus Aspergillus terreus Thorn. var terreus. World Journal of Microbiology and Biotechnology, 2005,21(6-7), 1067–1075.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₈O₆

[ Molecular Weight ]:
446.57600

[ Exact Mass ]:
446.26700

[ PSA ]:
78.90000

[ LogP ]:
4.76630

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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