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Semax

Names

[ CAS No. ]:
80714-61-0

[ Name ]:
Semax

[Synonym ]:
1,3,5-tris[6-isocyanatohexyl]-2,4,6-trioxo-s-triazine
HMDI trimer
tris(6-isocyanatohexyl) isocyanurate
L-2-methylleucine methyl ester
1,3,5-Tris(isocyanatohexamethylene)isocyanurate
Lys(Z)-OBzl.TosOH
H-MeLeu-OMe
hexamethylene diisocyanate isocyanurate
trimeric hexamethylene diisocyanate
H-Lys(Z)-OBzl*TosOH
H-Met-Glu-His-Phe-Pro-Gly-Pro
TsOH*H-Lys(Z)-OBzl
Desmodur N 3390 BA
Met-Glu-His-Phe-Pro-Gly-Pro

Biological Activity

[Description]:

MEHFPGP is a nootropic neuroprotective peptide. MEHFPGP can be used in the research of brain stroke[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

MEHFPGP (25 μM and 100 μM, 48 h) reduces the Abeta oligomers (100 μM) levels[2]. MEHFPGP (100 nM) increase survival of cholinergic basal forebrain neurons[3]. MEHFPGP (100 nM) stimulates activity of choline acetyltransferase in dissociated basal forebrain tissue culture[3]. MEHFPGP (10 μM, 24 h) stimulates the synthesis of brain-derived neurotrophic factor (BDNF) in astrocytes cultured from rat basal forebrain[4].

[In Vivo]

MEHFPGP (Semax, 100 μg/kg, i.p.) promotes the formation and functioning of the vascular system in Ischemia (pMCAO) rats[1]. MEHFPGP (50 µg and 250 µg, 100 µL/kg, intranasal inhalation) increases levels of b BDNF protein in rat basal forebrain[5]. Animal Model: Ischemia (pMCAO) rats[1]. Dosage: 100 μg/kg Administration: Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO). Result: Increased the immune response (upregulation of transcripts). Animal Model: Rats[5] Dosage: 50 µg, 250 µg, 100 µL/kg Administration: Intranasal inhalation Result: Increased levels of brain-derived neurotrophic factor (BDNF) protein in rat basal forebrain.

Chemical & Physical Properties

[ Density]:
1.391g/cm3

[ Boiling Point ]:
1335.2ºC at 760 mmHg

[ Molecular Formula ]:
C37H51N9O10S

[ Molecular Weight ]:
813.92000

[ Flash Point ]:
761.3ºC

[ Exact Mass ]:
813.34800

[ PSA ]:
325.58000

[ LogP ]:
2.71460

[ Index of Refraction ]:
1.617

MSDS

Click to get detail MSDS