1,1-Bis(p-chlorophenyl)methyl-carbinol
Names
[ CAS No. ]:
80-06-8
[ Name ]:
1,1-Bis(p-chlorophenyl)methyl-carbinol
[Synonym ]:
4-chloro-α-(4-chlorophenyl)-α-methylbenzenemethanol
1,1-bis(4-chlorophenyl)ethan-1-ol
MFCD00000628
4,4'-Dichloro-alpha-methylbenzhydrol
EINECS 201-246-3
4,4’-dichloro-α-methylbenzhydryl alcohol
1,1-bis(4-chlorophenyl)ethanol
Biological Activity
[Description]:
[Related Catalog]:
[Target]
dehydrochlorinase[1]
[References]
Chemical & Physical Properties
[ Melting Point ]:
69-71°C
[ Molecular Formula ]:
C14H12Cl2O
[ Molecular Weight ]:
267.15000
[ Exact Mass ]:
266.02700
[ PSA ]:
20.23000
[ LogP ]:
4.24920
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DC7875000
- CHEMICAL NAME :
- Benzhydrol, 4,4'-dichloro-alpha-methyl-
- CAS REGISTRY NUMBER :
- 80-06-8
- BEILSTEIN REFERENCE NO. :
- 2505345
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C14-H12-Cl2-O
- MOLECULAR WEIGHT :
- 267.16
- WISWESSER LINE NOTATION :
- GR DXQ1&R DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) Volume(issue)/page/year: 20,8,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,15,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 725 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,148,1968
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 72,304,1949
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H411
[ Precautionary Statements ]:
P273
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;N: Dangerous for the environment;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S36/37/39-S61-S36
[ RIDADR ]:
2811
[ RTECS ]:
DC7875000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Biophys. J. 83(5) , 2667-80, (2002)
The influence of salts (KCl, NaCl, CaCl(2), and MgCl(2)) on bicelles (bilayered micelles) made of dimyristoylphosphatidylcholine (DMPC, molar fraction X = 78%) and dicaproylphosphatidylcholine (DCPC) ...
Nonequilibrium phenomena in the phase separation of a two-component lipid bilayer.Biophys. J. 82(2) , 823-34, (2002)
Lipid bilayers composed of two phospholipids with significant acyl-chain mismatch behave as nonideal mixtures. Although many of these systems are well characterized from the equilibrium point of view,...
Binding of Ca2+ to the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum: equilibrium studies.Biochem. J. 297 ( Pt 3) , 615-24, (1994)
Equilibrium fluorescence methods have been used to establish a model for Ca2+ binding to the (Ca(2+)-Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum and to define the effects of H+ and Mg2+ on ...