DM3-SMe

Names

[ CAS No. ]:
796073-70-6

[ Name ]:
DM3-SMe

Biological Activity

[Description]:

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Maytansinoids


[References]

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

[2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H54ClN3O10S2

[ Molecular Weight ]:
812.43200

[ Exact Mass ]:
811.29400

[ PSA ]:
207.07000

[ LogP ]:
6.08820

Related Compounds