DM4-SMe

Names

[ CAS No. ]:
796073-68-2

[ Name ]:
DM4-SMe

Biological Activity

[Description]:

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Maytansinoids


[References]

[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.

[2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

Chemical & Physical Properties

[ Molecular Formula ]:
C39H56ClN3O10S2

[ Molecular Weight ]:
826.45900

[ Exact Mass ]:
825.31000

[ PSA ]:
207.07000

[ LogP ]:
6.47830

Related Compounds