BI-6C9

Names

[ Name ]:
BI-6C9

[Synonym ]:
N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide
BI-6C9

Biological Activity

[Description]:

BI-6C9 is a BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from cell death[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism

Research Areas >> Neurological Disease

[References]

[1]. Grohm J, et al. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 2010 Jul;24(5):831-8.

Chemical & Physical Properties

[ Density]:
1.368g/cm3

[ Molecular Formula ]:
C₂₃H₂₅N₃O₄S₂

[ Molecular Weight ]:
471.59200

[ Exact Mass ]:
471.12900

[ PSA ]:
144.20000

[ LogP ]:
6.25170

[ Index of Refraction ]:
1.671

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Differential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum.

Alcohol. Clin. Exp. Res. 39(1) , 55-63, (2015)

Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcoho...

Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma.

Invest. New Drugs 33(1) , 1-11, (2015)

The incidence and mortality of hepatocellular carcinoma (HCC) remain high worldwide. Drug screening from natural plants is one of the potential therapeutic approaches on HCC.The antitumor effect of mo...

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

J. Pharmacol. Exp. Ther. 350(2) , 273-89, (2014)

Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell l...

Related Compounds

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