Olanzapine D3

Names

[ Name ]:
Olanzapine D3

[Synonym ]:
Olanzapine-methyl-d3
2-methyl-4-(4-methyl-D3-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine
Oliza-d3
Oltal-d3
Integrol-d3
Zyprexa-d3
Olanzapine-d3
Oleanz-d3
Lanzac-d3

Biological Activity

[Description]:

Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is 5-HT2 and D1/D2 antagonist. Olanzapine is an antipsychotic agent with anticholinergic properties[1]. Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Signaling Pathways >> Autophagy >> Mitophagy

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Moore NA, et al. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51.

[2]. Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.

Chemical & Physical Properties

[ Density]:
1.337g/cm3

[ Boiling Point ]:
476.035ºC at 760 mmHg

[ Melting Point ]:
188-190ºC

[ Molecular Formula ]:
C₁₇H₁₇D₃N₄S

[ Molecular Weight ]:
315.45100

[ Flash Point ]:
241.697ºC

[ Exact Mass ]:
315.16000

[ PSA ]:
59.11000

[ LogP ]:
2.88860

[ Index of Refraction ]:
1.709

Related Compounds

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