7-Epi-10-deacetyltaxol

Names

[ Name ]:
7-Epi-10-deacetyltaxol

[Synonym ]:
Ormosin VI
10-Desacetyl-7-epipaclitaxel
10-Deacetyl-7-epi-taxol
7-Epi-10-deacetyltaxol
7-Epi 10-Desacetyl Paclitaxel
CS-1143
10-Deacetyl-7-epi-paclitaxel
7-Epi-10-deacetyl-taxol

Biological Activity

[Description]:

7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2).

[2]. Dang PH, et al.α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana. J Nat Prod. 2017 Apr 28;80(4):1087-1095.

Chemical & Physical Properties

[ Density]:
1.41±0.1 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
959.5℃ at 760 mmHg

[ Melting Point ]:
163-170?C

[ Molecular Formula ]:
C₄₅H₄₉NO₁₃

[ Molecular Weight ]:
811.86900

[ Exact Mass ]:
811.32000

[ PSA ]:
218.71000

[ LogP ]:
3.73970

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

[ Water Solubility ]:
Insuluble (2.4E-4 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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