Dermorphin TFA
Names
[ CAS No. ]:
78331-26-7
[ Name ]:
Dermorphin TFA
Biological Activity
[Description]:
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].
[Related Catalog]:
[Target]
μ-opioid receptor (MOR)[1]
[In Vitro]
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C42H51F3N8O12
[ Molecular Weight ]:
916.89600
[ Exact Mass ]:
916.35800
[ PSA ]:
332.91000
[ LogP ]:
1.92320