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Droxicainide

Names

[ CAS No. ]:
78289-26-6

[ Name ]:
Droxicainide

[Synonym ]:
als-1249
unii-j6w196lmv3
Droxicainide

Biological Activity

[Description]:

Droxicainide is an antiarrhythmic agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cardiovascular Disease

[In Vivo]

In coronary artery occlusion study, Droxicainide reduces hypoperfused area that evolves to necrosis, and reduces the infarct size in dogs[1]. Droxicainide decreases the sinus node, atrial and ventricular excitability and contractile force and increases the refractoriness in the study of spontaneously beating atria, electrically stimulated atria and papillary muscles isolated from rats[2].

[References]

[1]. Faria DB, et al. Effects of lidocaine and droxicainide on myocardial necrosis: a comparative study. J Am Coll Cardiol. 1983 Jun;1(6):1447-52.

[2]. Helgesen KG, et al. Comparison of electrophysiological and mechanical effects of droxicainide and lidocaine on heart muscle isolated from rats. Acta Pharmacol Toxicol (Copenh). 1984 Oct;55(4):303-7.


[Related Small Molecules]

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Chemical & Physical Properties

[ Density]:
1.133g/cm3

[ Boiling Point ]:
456.2ºC at 760 mmHg

[ Molecular Formula ]:
C16H24N2O2

[ Molecular Weight ]:
276.37400

[ Flash Point ]:
229.7ºC

[ Exact Mass ]:
276.18400

[ PSA ]:
56.06000

[ LogP ]:
2.67610

[ Index of Refraction ]:
1.578

[ Storage condition ]:
2-8℃

Related Compounds