Isoscopoletin

Names

[ CAS No. ]:
776-86-3

[ Name ]:
Isoscopoletin

[Synonym ]:
2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-
7-Methoxyesculetin
iso-Scopoletin
6-Hydroxy-7-methoxy-2H-chromen-2-one
6-hydroxy-7-methoxychromen-2-one
Isoscopoletin
EINECS 212-282-4

Biological Activity

[Description]:

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[References]

[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4.

[2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
413.5±45.0 °C at 760 mmHg

[ Melting Point ]:
206-208ºC

[ Molecular Formula ]:
C₁₀H₈O₄

[ Molecular Weight ]:
192.168

[ Flash Point ]:
172.4±22.2 °C

[ Exact Mass ]:
192.042252

[ PSA ]:
59.67000

[ LogP ]:
0.83

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.609

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-24/25-36-26

[ WGK Germany ]:
3

[ HS Code ]:
29322090

Related Compounds

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