Biotin alkyne

Names

[ Name ]:
Biotin alkyne

[Synonym ]:
Biotin propargylamide, 3-(D-Biotinylamido)-1-propyne, Prop-2-ynylamide biotin
5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(prop-2-ynyl)pentanamide

Biological Activity

[Description]:

Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Chemical & Physical Properties

[ Density]:
1.185±0.06 g/cm3(Predicted)

[ Boiling Point ]:
614.8±50.0 °C(Predicted)

[ Melting Point ]:
169-170 °C

[ Molecular Formula ]:
C₁₃H₁₉N₃O₂S

[ Molecular Weight ]:
281.37400

[ Exact Mass ]:
281.12000

[ PSA ]:
95.53000

[ LogP ]:
1.51010

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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