NSC-77053

Names

[ CAS No. ]:
77308-57-7

[ Name ]:
NSC-77053

Biological Activity

[Description]:

NSC-77053 is a potent BoNT/E inhibitor with an IC50 and a Ki of 2.4 μM and 1.29 μM, respectively[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: 2.4 μM (BoNT/E)[1]

[References]

[1]. Yuchen Zhou, et al. Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity. Bioorg Med Chem. 2016 Oct 15;24(20):4875-4889.

Chemical & Physical Properties

[ Density]:
1.315g/cm3

[ Boiling Point ]:
586.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₄O₃

[ Molecular Weight ]:
314.33400

[ Flash Point ]:
322.6ºC

[ Exact Mass ]:
314.09400

[ PSA ]:
54.37000

[ LogP ]:
4.18700

[ Index of Refraction ]:
1.682

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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