Kuwanon H

Names

[ Name ]:
Kuwanon H

[Synonym ]:
Albanin G
Alvanin G
kuwanon H
Moracenin A
NSC 356889

Biological Activity

[Description]:

Kuwanon H is a flavonoid isolated from Morus bombycis, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor

[Target]

Ki: 290 nM (GRP-preferring recepotr)[1]

[References]

[1]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.

Chemical & Physical Properties

[ Density]:
1.371g/cm3

[ Boiling Point ]:
969.8ºC at 760 mmHg

[ Molecular Formula ]:
C₄₅H₄₄O₁₁

[ Molecular Weight ]:
760.82400

[ Flash Point ]:
292.5ºC

[ Exact Mass ]:
760.28800

[ PSA ]:
209.12000

[ LogP ]:
8.83870

[ Index of Refraction ]:
1.681

[ Water Solubility ]:
Insuluble (3.5E-6 g/L) (25 ºC)

Kuwanon H

Names

Biological Activity

Chemical & Physical Properties

Related Compounds