β-Endorphin (30-31) (human)

Names

[ Name ]:
β-Endorphin (30-31) (human)

[Synonym ]:
L-Glutamic acid, N-glycyl-
N-glycylglutamic acid
H2N-glycine-Acide glutamique-OH
EINECS 231-019-4
H-Gly-Glu-OH
Glycylglutamic acid
Gly-L-Glu-OH
L-Glutamic acid,N-glycyl
GLY-GLU
MFCD00008128
Glycyl-L-glutamic acid
L-Glutamic acid, glycyl-
N-glycyl-L-glutamic acid
Gly-Glu-OH

Biological Activity

[Description]:

Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Acetylcholinesterase

[References]

[1]. Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5213-7.

[2]. Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
536.6±50.0 °C at 760 mmHg

[ Melting Point ]:
155-158ºC (dec.)(lit.)

[ Molecular Formula ]:
C₇H₁₂N₂O₅

[ Molecular Weight ]:
204.181

[ Flash Point ]:
278.3±30.1 °C

[ Exact Mass ]:
204.074615

[ PSA ]:
129.72000

[ LogP ]:
-2.68

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.537

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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