β-Endorphin (30-31) (bovine, camel, mouse, ovine)

Names

[ Name ]:
β-Endorphin (30-31) (bovine, camel, mouse, ovine)

[Synonym ]:
H-Gly-Gln-OH
Gly-l-Gln
(2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoic acid
(S)-2-(2-Aminoacetylamino)-4-carbamoylbutyric acid
MFCD00077124
L-Glutamine, glycyl-
(2S)-5-Amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid
ZV2YVQMV1Z &&L or S Form
(S)-5-Amino-2-(2-aminoacetamido)-5-oxopentanoic acid
Glycyl-L-glutamine

Biological Activity

[Description]:

Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems[1]. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln)[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide. Glycyl-glutamine (Glycyl-L-glutamine) has an advantage over free glutamine (Gln) as growth factors for cell culture during both autoclaving and storage[2].

[In Vivo]

Glycyl-glutamine (Glycyl-L-glutamine) (0.3, 0.6, 1.0 and 10.0 nM) can dose-dependently inhibit beta-End-(1-31)-induced hypotension in pentobarbital-anesthetized rats[1].

[References]

[1]. Unal CB1, et al. Beta-endorphin-induced cardiorespiratory depression is inhibited by glycyl-L-glutamine, a dipeptide derived from beta-endorphin processing.J Pharmacol Exp Ther. 1994 Nov;271(2):952-8

[2]. Roth E, et al. Influence of two glutamine-containing dipeptides on growth of mammalian cells.In Vitro Cell Dev Biol. 1988 Jul;24(7):696-8.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
643.1±55.0 °C at 760 mmHg

[ Melting Point ]:
194°C

[ Molecular Formula ]:
C₇H₁₃N₃O₄

[ Molecular Weight ]:
203.196

[ Flash Point ]:
342.7±31.5 °C

[ Exact Mass ]:
203.090607

[ PSA ]:
144.74000

[ LogP ]:
-2.50

[ Vapour Pressure ]:
0.0±4.1 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
154 g/L (20 ºC)

MSDS

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Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S24/25-S37/39-S26

[ WGK Germany ]:
-

[ HS Code ]:
2924199090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%