SCH 50911

Names

[ Name ]:
SCH 50911

[Synonym ]:
SCH-50911
Sch 50911
(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid
(2S)-(+)-5,5-dimethyl-2-morpholineacetic acid
SCH 50911
(2S)-5,5-dimethyl-2-morpholineacetic acid
WS 3

Biological Activity

[Description]:

SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABA(B):1.1 μM (IC50)

[References]

[1]. Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362(1):35-41.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₅NO₃

[ Molecular Weight ]:
173.21000

[ Exact Mass ]:
173.10500

[ PSA ]:
58.56000

[ LogP ]:
0.55690

Related Compounds

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