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AMP PNP

Names

[ CAS No. ]:
72957-42-7

[ Name ]:
AMP PNP

[Synonym ]:
tetralithium
Adenylyl imidodiphosphate tetralithium salt
MFCD03424105
adenylyl-imidodiphosphate tetralithium
AMP-PNP
EINECS 277-127-5

Biological Activity

[Description]:

AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

AMP-PNP (5 to 500 μM; Li salt) reduced the open-probability po of KATP channels and decreases the single-channel currents at high nucleotide concentrations by approximately 10%[2]. AMP-PNP inhibits KATP channels of ventricular myocytes and of pancreatic β-cells both in the absence and presence of Mg2+ ions[2].

[References]

[1]. I M Rybakowska, et al. Activities of purine converting enzymes in heart, liver and kidney mice LDLR-/- and Apo E-/. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):340-347.

[2]. S Hehl, et al. KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur Biophys J. 1994;23(4):231-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H13Li4N6O12P3

[ Molecular Weight ]:
529.92900

[ Exact Mass ]:
530.04400

[ PSA ]:
322.68000

[ LogP ]:
0.66890

[ Storage condition ]:
-20°C

Safety Information

[ Safety Phrases ]:
S22-S24/25

Related Compounds