Dynorphin A (1-13)

Names

[ Name ]:
Dynorphin A (1-13)

[Synonym ]:
UNII:VFC23V742Z
dynorphin A-(1-13)
DYNORPHIN 1-13
DYNORPHIN A (1-13),PORCINE
dyn A-(1-13)-OH
L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-L-lysine
DYNORPHIN A(HUMAN,1-13)
YGGFLRRIRPKLK
L-Lysine, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
Dyn(1-13)
DYNORPHIN A PORCINE FRAGMENT 1-13
Dynorphin A (1-13) Acetate
Porcine dynorphin A(1-13)

Biological Activity

[Description]:

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Peptides

[Target]

Κ opioid receptor[1].

[In Vivo]

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

[References]

[1]. Hauser KF, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₇₅H₁₂₆N₂₄O₁₅

[ Molecular Weight ]:
1603.955

[ Exact Mass ]:
1602.983398

[ PSA ]:
661.70000

[ LogP ]:
-0.50

[ Index of Refraction ]:
1.645

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.

J. Med. Chem. 43(7) , 1251-2, (2000)

Central reinforcing effects of ethanol are blocked by catalase inhibition.

Alcohol 41(7) , 525-34, (2007)

Recent studies have systematically indicated that newborn rats are highly sensitive to ethanol's positive reinforcing effects. Central administrations of ethanol (25-200mg %) associated with an olfact...

Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat.

Neurosci. Res. 54(1) , 49-56, (2006)

Our previous study proved that the hypothalamic paraventricular nucleus (PVH) plays an important role in acupuncture analgesia. The neuropeptides involving in the PVH regulation of acupuncture analges...