Losulazine
Names
Chemical & Physical Properties
[ Density]:
1.454g/cm3
[ Boiling Point ]:
695.7ºC at 760 mmHg
[ Molecular Formula ]:
C27H22F4N4O3S
[ Molecular Weight ]:
558.54700
[ Flash Point ]:
374.5ºC
[ Exact Mass ]:
558.13500
[ PSA ]:
90.99000
[ LogP ]:
6.31260
[ Index of Refraction ]:
1.638
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM0829800
- CHEMICAL NAME :
- Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethy l)-4-quinolinyl)amino) benzoyl)-
- CAS REGISTRY NUMBER :
- 72141-57-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C27-H22-F4-N4-O3-S
- MOLECULAR WEIGHT :
- 558.59
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,133,1986 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 168 mg/kg
- SEX/DURATION :
- lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 33,36C,1986
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Related Compounds
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