ADENOSINE 5'-TRIPHOSPHATE,PERIODATE OXIDIZED SODIUM SALT

Names

[ CAS No. ]:
71997-40-5

[ Name ]:
ADENOSINE 5'-TRIPHOSPHATE,PERIODATE OXIDIZED SODIUM SALT

[Synonym ]:
MFCD00056956

Biological Activity

[Description]:

Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[Target]

NLRP3 inflammasome

P2X7 Receptor

[In Vivo]

Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2]. Animal Model: Induced mouse experimental autoimmune uveitis (EAU)[2] Dosage: 300 μg/mouse Administration: i.p. Result: Showed almost undetected EAU, as shown by fundoscopic and pathologic examination. Decreased serum IL-17 level. Mitigated the autoreactive T cell response.

[References]

[1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40.

[2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₁N₅Na₃O₁₃P₃

[ Molecular Weight ]:
571.11

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Involvement of a P2X7 Receptor in the Acrosome Reaction Induced by ATP in Rat Spermatozoa.

J. Cell Physiol. 230 , 3068-75, (2015)

The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non-physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse ...

P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions.

J. Virol. 89 , 9368-82, (2015)

HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to be necessary and sufficient to pro...

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance.

Proc. Natl. Acad. Sci. U. S. A. 112(9) , 2835-40, (2015)

Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated period...