Substance P (free acid)

Names

[ CAS No. ]:
71977-09-8

[ Name ]:
Substance P (free acid)

[Synonym ]:
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH
RPKPQQFFGLM
H-RPKPQQFFGLM-OH
RPKPQQFFGLM-OH
[Met-OH11] substance P
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
Substance P, free acid

Biological Activity

[Description]:

Substance P, Free Acid is a native substance P analog, but shows no biological activity of substance P.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Others

[References]

[1]. Patel AB, et al. Substance P (free acid) adopts different conformation than native peptide in DMSO, water and DPPC bilayers. J Biomol Struct Dyn. 2001 Aug;19(1):129-38.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.41 g/cm3

[ Molecular Formula ]:
C₆₃H₉₇N₁₇O₁₄S

[ Molecular Weight ]:
1348.61000

[ Exact Mass ]:
1347.71000

[ PSA ]:
536.14000

[ LogP ]:
4.09310

[ Storage condition ]:
2-8℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Synthesis of peptides by the solid-phase method. 7. Substance P and analogues.

J. Med. Chem. 25 , 64, (1982)

Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the comp...

Biological activity of substance P methyl ester.

Mol. Pharmacol. 20 , 457, (1981)