Bovine Pineal Antireproductive Tripeptide acetate salt

Names

[ Name ]:
Bovine Pineal Antireproductive Tripeptide acetate salt

[Synonym ]:
H-Thr-Ser-Lys-OH
THR-SER-LYS
threonyl-seryl-lysine
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE
thr-ser-lys acetate
threonine-serine-lysine acetate
H-THR-SER-LYS-OH ACETATE SALT
L-Lysine,N2-(N-L-threonyl-L-seryl)
THR-SER-LYS (THR-SER-LYS ACETATE)

Biological Activity

[Description]:

Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[In Vivo]

Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice[1]. Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats[2]. Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice[4]. Animal Model: Unilaterally ovariectomized (UO) mice Dosage: 175 ng Administration: Intraperitoneal injection (i.p.) Result: Reduced serum follicle stimulating hormone (FSH) in UO mice.

[References]

[1]. Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5.

[2]. Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7.

[3]. Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28.

[4]. Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172.