71730-64-8

71730-64-8 structure

Name: Bovine Pineal Antireproductive Tripeptide acetate salt
Chemical Name: Bovine Pineal Antireproductive Peptide
CAS Number: 71730-64-8
Molecular Formula: C₁₃H₂₆N₄O₆
Molecular Weight: 334.36900
Catalog: Research Areas Endocrinology
Create Date: 2018-10-11 11:23:21
Modify Date: 2024-01-09 18:08:13
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].

Name	Bovine Pineal Antireproductive Peptide
Synonyms	H-Thr-Ser-Lys-OH THR-SER-LYS threonyl-seryl-lysine BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE thr-ser-lys acetate threonine-serine-lysine acetate H-THR-SER-LYS-OH ACETATE SALT L-Lysine,N2-(N-L-threonyl-L-seryl) THR-SER-LYS (THR-SER-LYS ACETATE)

Description	Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
In Vivo	Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice[1]. Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats[2]. Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice[4]. Animal Model: Unilaterally ovariectomized (UO) mice Dosage: 175 ng Administration: Intraperitoneal injection (i.p.) Result: Reduced serum follicle stimulating hormone (FSH) in UO mice.
References	[1]. Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5. [2]. Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7. [3]. Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28. [4]. Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172.

Density	1.319g/cm3
Boiling Point	770ºC at 760 mmHg
Molecular Formula	C₁₃H₂₆N₄O₆
Molecular Weight	334.36900
Flash Point	419.5ºC
Exact Mass	334.18500
PSA	188.00000
Index of Refraction	1.552

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