(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

Names

[ CAS No. ]:
716-61-0

[ Name ]:
(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

[Synonym ]:
2-Amino-1-(4-nitrophenyl)-1,3-propanediol
2-amino-1-(4-nitrophenyl)propane-1,3-diol
D-(-)-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
D-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-
D-threo-(-)-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
1-(p-nitrophenyl)-2-amino-1,3-propanediol
MFCD00078126
1,3-Propanediol, 2-amino-1- (p-nitrophenyl)-
1,3-Propanediol, 2-amino-1- (4-nitrophenyl)-
1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, D-threo-(-)-
EINECS 211-938-7

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
451.9±45.0 °C at 760 mmHg

[ Melting Point ]:
163-165ºC

[ Molecular Formula ]:
C₉H₁₂N₂O₄

[ Molecular Weight ]:
212.203

[ Flash Point ]:
227.1±28.7 °C

[ Exact Mass ]:
212.079712

[ PSA ]:
112.30000

[ LogP ]:
0.13

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY3100000

CHEMICAL NAME :: 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, D-threo-(-)-

CAS REGISTRY NUMBER :: 716-61-0

LAST UPDATED :: 199406

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H12-N2-O4

MOLECULAR WEIGHT :: 212.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,207,1994

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 3259

[ WGK Germany ]:
3

[ RTECS ]:
TY3100000

Articles

[Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent].

Yao Xue Xue Bao 25(6) , 430-4, (1990)

Threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 was found to be a useful resolving agent for racemic gossypol. The optical and chemical stability of the condensate of enantiomeric gossyp...

Investigation of Batten disease with the yeast Saccharomyces cerevisiae.

Mol. Genet. Metab. 66(4) , 314-9, (1999)

The CLN3 gene, which encodes the protein whose absence is responsible for Batten disease, the most common inherited neurovisceral storage disease of childhood, was identified in 1995. The function of ...

High-performance liquid chromatographic determination of chloramphenicol and 2-amino-1-(p-nitrophenyl)-1,3-propanediol in pharmaceutical formulations.

J. Chromatogr. A. 170(1) , 282-7, (1979)