Brimonidine L-tartrate

Names

[ Name ]:
Brimonidine L-tartrate

[Synonym ]:
Brimonidine tartrate
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine tartrate
(2R,3R)-2,3-Dihydroxysuccinic acid - 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (1:1)
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine L-tartrate
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, (2R,3R)-2,3-dihydroxybutanedioate
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (1:1)
MFCD07773086
UK 14,304 (tartrate)

Biological Activity

[Description]:

UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.Target: α2-adrenergic Receptor[3H]UK 14,034 is a full agonist at alpha 2-adrenergic receptors. [3H]UK 14,304 labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Others

[References]

[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.

[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.

[3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
432.6ºC at 760 mmHg

[ Melting Point ]:
207-208ºC (dec.)

[ Molecular Formula ]:
C₁₅H₁₆BrN₅O₆

[ Molecular Weight ]:
442.221

[ Flash Point ]:
215.4ºC

[ Exact Mass ]:
441.028381

[ PSA ]:
177.26000

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P305 + P351 + P338

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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