TCMDC-124283
Names
[ CAS No. ]:
700-49-2
[ Name ]:
TCMDC-124283
[Synonym ]:
2-fluoro-adenin
2-FLUORO-6-AMINOPURINE
7H-Purin-6-amine, 2-fluoro-
2-fluoro-9H-purin-6-amine
2-Fluoroadenine
6-AMINO-2-FLUOROPURINE
TCMDC-124283
MFCD01632749
2-fluoropurine
2-fluoroadenibe
2-Fluoro-1H-purin-6-amine
2-fad
6-amino-2-fluoro-purin
BUTTPARK 25 1-01
2-fluoradenine
2-fluoro-1h-purin-6-amin
Biological Activity
[Description]:
[Related Catalog]:
[Target]
DNA/RNA synthesis[1]
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.7±0.1 g/cm3
[ Boiling Point ]:
676.9±58.0 °C at 760 mmHg
[ Melting Point ]:
>350 °C(lit.)
[ Molecular Formula ]:
C5H4FN5
[ Molecular Weight ]:
153.12
[ Flash Point ]:
363.2±32.3 °C
[ Exact Mass ]:
153.045074
[ PSA ]:
80.48000
[ LogP ]:
-0.01
[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C
[ Index of Refraction ]:
1.783
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AU6264700
- CHEMICAL NAME :
- Adenine, 2-fluoro-
- CAS REGISTRY NUMBER :
- 700-49-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C5-H4-F-N5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11340 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
AU6264700
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
BMC Cancer 14 , 547, (2014)
Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellu...
Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.PLoS ONE 9(6) , e98818, (2014)
The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET(A)R and ETBR), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involv...
Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine.Nucleosides Nucleotides Nucleic Acids 25(7) , 735-45, (2006)
The reaction between 2-fluoroadenine (3) and 1,3,5-tri-O-benzyl-1-alpha-D-chloroarabinofuranose (4) with potassium t-amylate was evaluated in various solvents to afford 9-beta-D-(2,3,5-tri-O-benzyl-ar...