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N-Boc-DL-serine methyl ester

Names

[ CAS No. ]:
69942-12-7

[ Name ]:
N-Boc-DL-serine methyl ester

[Synonym ]:
Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
Methyl N-(tert-butoxycarbonyl)serinate
Methyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}serinate
methyl 3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
N-Boc-DL-serine methyl ester

Biological Activity

[Description]:

N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Yang Yongqing, et al. Method for synthesizing α,β-dehydro-α-amino acid. Patent CN105037210.

[2]. Wu Chengde, et al. Preparation of quinazolinone derivatives useful as PI3Kα inhibitors for the treatment of cancer. Patent WO2019091476.

[3]. Pastor Fernandez, et al. Preparation of tricyclic pyrolopyranopyridines as protein kinase inhibitors. Patent WO2017033019.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
354.3±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H17NO5

[ Molecular Weight ]:
219.235

[ Flash Point ]:
168.1±25.1 °C

[ Exact Mass ]:
219.110672

[ PSA ]:
88.35000

[ LogP ]:
0.80

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.461

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds