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BoNT-IN-1

Names

[ CAS No. ]:
694443-03-3

[ Name ]:
BoNT-IN-1

[Synonym ]:
8-Quinolinol, 2-methyl-7-[[(4-methyl-2-pyridinyl)amino](2-nitrophenyl)methyl]-
2-Methyl-7-{[(4-methyl-2-pyridinyl)amino](2-nitrophenyl)methyl}-8-quinolinol

Biological Activity

[Description]:

BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A light chain (BoNTA LC) with IC50 of 0.9 uM.IC50 value: 0.9 uMTarget: BoNT in vitro: BoNT-IN-1 targets BoNT/A LC enzymatic activity,is highly efficient in vitro, BoNT-IN-1 has good property in cell-based, as well as tissue-based assays.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Caglic D, et al. Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain. J Med Chem. 2014 Feb 13;57(3):669-676.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
633.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H20N4O3

[ Molecular Weight ]:
400.430

[ Flash Point ]:
337.2±30.1 °C

[ Exact Mass ]:
400.153534

[ LogP ]:
4.39

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.717

[ Storage condition ]:
2-8℃

Related Compounds