3-(4-methylphenyl)-1-(1,3-thiazol-2-yl)urea

Names

[ Name ]:
3-(4-methylphenyl)-1-(1,3-thiazol-2-yl)urea

[Synonym ]:
1-thiazol-2-yl-3-(4-methylphenyl)urea
1-thiazol-2-yl-3-p-tolyl-urea

Biological Activity

[Description]:

Anticancer agent 38 (compound 19), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 38 inhibits A431 cell growth with an IC50 of 5.2 µg/mL[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Farid M. Sroor, et al. Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies. Medicinal Chemistry Research volume 31, pages400–415 (2022).

Chemical & Physical Properties

[ Density]:
1.381g/cm3

[ Molecular Formula ]:
C₁₁H₁₁N₃OS

[ Molecular Weight ]:
233.29000

[ Exact Mass ]:
233.06200

[ PSA ]:
82.26000

[ LogP ]:
3.24150

[ Index of Refraction ]:
1.715

Safety Information

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%