JNK-IN-11

Names

[ CAS No. ]:
676594-38-0

[ Name ]:
JNK-IN-11

Biological Activity

[Description]:

JNK-IN-11 (compound 1) is a potent JNK inhibitor with an IC50 value of 2.2, 21.4, 1.8 µM for JNK1, JNK2, JNK3, respectively. JNK-IN-11 has the potential for the research of alzheimer and parkinson disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK1:1.8 μM (IC50)

JNK3:2.2 μM (IC50)

JNK2:21.4 μM (IC50)


[References]

[1]. Hom RK, et al. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H11NO3S2

[ Molecular Weight ]:
281.35

Related Compounds