N-Butanoyl-L-homoserine lactone

Names

[ Name ]:
N-Butanoyl-L-homoserine lactone

[Synonym ]:
C4-homoserine lactone
Butanamide, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
N-Butyryl-DL-homoserin-lacton
HL4
N-Butyryl-L-homoserine lactone
N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide
(+)-a(S)-butyr-amido-r-butyrolactone
N-[(3S)-2-Oxotetrahydro-3-furanyl]butanamide
butanoyl homoserine lactone

Biological Activity

[Description]:

N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
428.1±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₃NO₃

[ Molecular Weight ]:
171.194

[ Flash Point ]:
212.7±25.7 °C

[ Exact Mass ]:
171.089539

[ PSA ]:
55.40000

[ LogP ]:
-1.10

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.476

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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