clofenamide

Names

[ CAS No. ]:
671-95-4

[ Name ]:
clofenamide

[Synonym ]:
Frictan
Eleklin
4-chloro-benzene-1,3-disulfonic acid diamide
Aponiere
Indigatin
4-Chlor-benzol-1,3-disulfonamid
Haflutan
Monochlorphenamide
4-Chlor-benzol-1,3-disulfonsaeure-diamid
Diumide
1-Chlor-2,4-bis-sulfamoyl-benzol
Clofenamide
Mahi
4-chloro-benzene-1,3-disulfonamide
Aquedux

Biological Activity

[Description]:

Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

Research Areas >> Metabolic Disease

[References]

[1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.

Chemical & Physical Properties

[ Density]:
1.699g/cm3

[ Boiling Point ]:
551.6ºC at 760 mmHg

[ Melting Point ]:
206-207° (Davies); mp 217-219° (Olivier)

[ Molecular Formula ]:
C₆H₇ClN₂O₄S₂

[ Molecular Weight ]:
270.71

[ Flash Point ]:
287.4ºC

[ Exact Mass ]:
269.95400

[ PSA ]:
137.08000

[ LogP ]:
3.19700

[ Index of Refraction ]:
1.627

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9100000

CHEMICAL NAME :: m-Benzenedisulfonamide, 4-chloro-

CAS REGISTRY NUMBER :: 671-95-4

BEILSTEIN REFERENCE NO. :: 2142672

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H7-Cl-N2-O4-S2

MOLECULAR WEIGHT :: 270.72

WISWESSER LINE NOTATION :: ZSWR BG ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 661 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

Safety Information

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

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