CL 218872

Names

[ Name ]:
CL 218872

[Synonym ]:
CL 218,872
Tocris-1709

Biological Activity

[Description]:

CL 218872 is a selective and orally active benzodiazepine of α1 subunit-containing GABAAreceptor with a Ki of 130 nM. CL 218872 exerts anxiolytic and anticonvulsant in vivo[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Squires RF, et al. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol Biochem Behav. 1979 May;10(5):825-30.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Molecular Formula ]:
C₁₃H₉F₃N₄

[ Molecular Weight ]:
278.23300

[ Exact Mass ]:
278.07800

[ PSA ]:
43.08000

[ LogP ]:
3.11850

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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